Clozapine – receptors affected by it

Clozapine Has Such Affinity for Dopamine

  • Cholinergic
  • Histaminergic
  • Serotonergic
  • Adrenergic
  • Dopaminergic

Greater affinity to D4 than D2 receptors. D4 receptors are highest in the frontal cortex and amygdala and low in the basal ganglia. D2 receptors are higher in the basal ganglia so this may explain why there are reduced extra-pyramidal side effects (EPSE) with clozapine compared to other atypical antipsychotics.